Measuring nicotine consumption is a challenge. Nicotine directly affects the adrenal glands, releasing adrenaline, which in turn stimulates the individual.
The body experiences immediate release of glucose and an increase in heart rate, breathing, and blood pressure as the surge of adrenaline stimulates the body.
There is also a correlation between lower insulin production and nicotine use, causing a slight increase in glucose (blood sugar) in the body.
The individual experiences mild euphoria as nicotine causes the brain to release dopamine, which is directly linked to feelings of pleasure.